Each tablet contains: 37.5 mg tramadol hydrochloride Paracetamol 325 mg Excipient c.b.p. 1 tablet. Each tablet contains: 18.75 mg tramadol hydrochloride Paracetamol 162.5 mg Excipient c.b.p. 1 tablet. Route of administration: Oral. Tramacet Â® should be administered as follows: Adults (over 16 years): The recommended dose is Tramacet Â® 1-2 tablets every 4-6 hours, according to the response to pain relief, up 8 tablets per day. Some patients may benefit from a starting dose titration Tramacet Â® 18.75 mg / 162.5 mg every 4-6 hours to improve tolerability. Tramacet Â® can be administered with food. The pain long term Tramacet Â® should be initiated with 1 tablet / day and titrated every three days in increments of 1 tablet, if well tolerated, up to 4 tablets (150 mg of tramadol / 1,300 mg of paracetamol) by day. Subsequently Tramacet Â® can be administered every 6 to 8 hours to a maximum of 8 tablets per day, as needed. Based on experience with Tramadol HCL, one component of Tramacet Â®, adjusting the dose that results in lower rates of discontinuation is recommended. Pediatric patients (under 16 years): The safety and efficacy of Tramacet Â® has not been established in pediatric patients. Elderly: No overall differences were found regarding the safety and pharmacokinetics in adults Â³ 65 years and young adults.